Manufacturing Scale-Up of Electrospun Nanofibers

Professor Kim Woodrow and PhD student Emily Krogstad in the University of Washington Department of Bioengineering have demonstrated the scale-up of their laboratory’s electrospinning process to create nanofiber materials for vaginal drug delivery at scale. In the study published in the International Journal of Pharmaceutics, the researchers show that their novel fabric material can be scaled up from a laboratory process to achieve production of the anti-HIV drug-eluting fibers in a nozzle-free, production-scale system. This scale-up represents an important development in the translation of this drug-eluting nanofiber technology to a production-scale system that can support the development of Empreva.

Krogstad & Woodrow, "Manufacturing scale-up of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery," International Journal of Pharmaceutics 1-2: 282–291 (Nov. 2014)

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